6/13/2023 0 Comments Als stem cell treatment 2015“It is not a process where you get everything you want – you sometimes get impurities, so we have a method and patent to take the right cells and put them in the patient. In fact, Kadimastem is the only cell therapy company with this capability. Kadimastem is also developing technology to purify non-relevant cells from the production procedure by selecting the right cells to put in the patient. In mice, we were able to show the dose escalating needed in order to achieve normal glycaemia, so we know most of the things that we need to know about these cells.” “In diabetes, we have managed to demonstrate that we have the capability to manufacture the islets in a good, reproducible way and our proof-of-concept studies show that our cells are capable of ameliorating glycaemia in diabetic animals. “We anticipate that in about two years our diabetes product will be in clinical trials,” says Molakandov. In April 2021, the company announced it had secured $6.8 million in financing to expedite its research and development programmes. The company aims to test multiple injections of AstroRx cells in the next round of clinical trials to try to prolong the beneficial effect.įor IsletRx, Kadimastem is working with global regulatory authorities to start pre-clinical studies this year. The study results show a high safety profile of AstroRx cells and also demonstrated that this particular approach significantly decreased the progression of the disease for three months after AstroRx administration, when measured by ALS Functional Rating Scale-Revised (ALSFRS-S). In March 2021, the company completed a Phase 1/2a clinical trial at Jerusalem’s Hadassah Medical Center, which validated safety and efficacy. The astrocyte cells are injected directly into the cerebrospinal cord fluid of the patients to support the dying motor neurons in the brain and spinal cord of ALS patients and slow progression of the disease. Kadimastem’s lead product for ALS, AstroRx, is a cell therapy product containing astrocytes derived from human embryonic stem cells. We just accelerate the process that takes place in utero over nine months and follow the same stages in a shorter time period.” We have ways to maneuver stem cells to the destination and target tissue we want. “We see the cells like clay in our hands that we manipulate in culture and mimic development processes. “Any tissue in the body can be made from the stem cells as they are immature, very easy to work with cells and can proliferate as much as we want to become whatever we want,” says Molakandov. After developing treatments for multiple sclerosis, he turned his focus to two main disease areas – diabetes and ALS. You have to calculate everything from how much you eat, the amount of insulin to inject, and how much physical exercise to take – everything has to be managed! With our therapy, we aim to make it easy by simply putting the functional cells in the patient,” Molakandov tells pharmaphorum.įounded in 2009 by Kadimastem’s chief scientist Professor Michel Revel, the therapy is based on stem cell research from Israel’s Weizmann Institute of Science, looking at the potential of restoring activity lost in tissues due to disease damage. “Diabetes is a very hard disease to manage, especially with young children. Using micro-encapsulation technology, integrated within IsletRx, the islet cells are protected from attack by the host immune system. The product in development, IsletRx, is clinical grade pancreatic islet cells which produce and secrete insulin and glucagon in response to blood glucose levels. The Tel-Aviv listed company is leading research and development of a cell therapy comprising functional pancreatic islet cells. Every donor is different, and if you offer a therapy, it should be good, reliable, consistent, and the same for everyone.”Īs the head of diabetes research at Israeli cell therapy company Kadimastem, Molakandov believes they could have the next major diabetes therapy. “But even if there were enough donor islets, the standardisation of this therapy is horrible. “Only a few thousand people have benefited from this therapy as there are not enough donors,” says Kfir Molakandov. But years later, the potential of islet therapy is yet to be realised due to difficulties finding donors and harvesting cells. In the 1990s, when the first transplant of islets took place, it was hailed as the cure for diabetes. Catherine Longworth spoke with Kadimastem’s head of diabetes research, Kfir Molakandov to find out more. Israeli company Kadimastem is developing regenerative medicine therapies based on differentiated cells derived from human embryonic stem cells to treat diseases such as Amyotrophic lateral sclerosis (ALS) and diabetes.
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6/13/2023 0 Comments San pietro island art of rallyShame on you! Get your facts correct before treating your customers this way. When we went to get on the boat to return to the hotel we were shouted at across the street by a very loud irate 'lady' who advised us the trip was one way only! What a way to treat your customers! Take their money and then verbally abuse them after providing them with incorrect information. The older gentleman who was our 'guide' advised we could return to the hotel on their boat and gave us the times it would be leaving. We literally had to ask the way out as there was no clear exit. The glass tour starts with about a five minute demonstration of watching a 'master' at work and then a tour of their showrooms for the next hour you are watched and followed continuously (not a comfortable feeling at all) and if you show any interest in any product you then receive a detailed account of the product and their offer of a 50% discount but still at a ludicrous price. Our hotel suggested a free tour of this glass factory with a boat pick-up right outside the hotel. A sales trap, as previously advised by other reviewers. On the island of San Pietro you will experience the thrill of rugged coasts and wild sea, you will feel the intense scents of the Mediterranean bush, you will see the flight of rare birds, you will savor the delicacies deriving from tuna fishing.įor a lovely and unforgettable stay, have a look at some of the most beautiful luxury villas for rent in Sardinia.I would have given no stars for this company if I could. The municipality stands on the remains of Sulki, one of the oldest cities in the western Mediterranean. The only inhabited center of the island is Sant ’Antioco with 11 thousand inhabitants and is located south of the island. It is the best way to appreciate the beauty of this island and its seabed while admiring the most hidden places! You can have fun and enjoy numerous baths in the crystal clear sea of Sardinia in the countless white beaches. Pietro from the sea you will closely observe its splendid cliffs, the countless caves inaccessible from the ground and you can admire the colonies of the Queen's falcon, a bird of prey difficult to see from the coast. Onboard a splendid dinghy, you will visit the island of S. Transparent waters, pristine and wild coves, cliffs overlooking the sea offer indescribable emotions. The beaches are equipped with all comforts to guarantee you a day full of relaxation and fun. An emerald sea kisses the island in a context of suggestive landscapes. The beaches of the island of San Pietro are renowned for their exquisitely still virgin aspect. The pristine sea that surrounds this still wildland, south-west of Sardinia, will give you the privilege of admiring its submerged wonders, offering you always new emotions every time. With over 50 square kilometers of territory, it is the second-largest island, after Sant’Antioco, in the Sulcis archipelago. It is the realm of diving, snorkeling, sport fishing and bird watching. The island has high and jagged cliffs, eroded by the crystal clear sea, where inlets with enchanting coves open. The island is mainly of volcanic origin, but the volcano has been completely inactive for at least 15-20 million years. Inhabited since prehistoric times and called the "island of the sparrow hawks" by the Punic, the island of San Pietro is located in the south-western tip of Sardinia, facing the Sulcitan coast. 6/13/2023 0 Comments Rc mini racers hackedOur Generator Encrypt Data to ensure maximum protection and minimal risk.ĭid you prefer not to buy Coins just get them for free? Or you need an updated RC Mini Racers Hack that worked on their current version? Well, it is so easy even a 10-year-old child can do it!Īnd it’s true hack for Coins can get you ahead in this game. So if you're stuck somewhere, or just for fun, or to go beyond a level where you're struggling or to become one of the best players use our Generator and get what ever you want. 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RC Mini Racers Hack Unlimited Coins Android | iOS ! 100% Work Any Joypad or Joystick as well as the keyboard can be used to control your car.RC Mini Racers Hack Mod APK Get Unlimited Coins Cheats Generator IOS Android Graphics settings can be adjusted and tweaked in detail to let the game run perfectly on your machine. RC Mini Racers runs in any native resolution your Windows or Mac PC offers – in windowed and fullscreen mode. Hours of fun guaranteed until you unlocked all tracks in all difficulty modes! Use that in-game cash to unlock other tracks or convert them to coins for use in the car pimp shop.Īll tracks can be raced in 4 difficulty modes ranging from easy to medium over to hard and finally the insane mode. You get cash for crashing other cars, explosions caused by missiles and mines that affect other cars, for jumping over epic ramps and getting airtime cash, for driving best laps and best race times as well as for winning the top spot ranks in a race. Find out yourself which tracks you like most!įor nearly every action during a race you get in-game cash rewarded. RC Mini Racers has a great mixture of tracks where you need your weapons to win the race by shooting and bombing your opponents from the track but also fantastic high speed tracks where it is mostly down to great driving skills to win the race. Beside that there’s a coin racing mode where you can explore the level and collect coins for the in-game store. The game features 24 tracks separated in circuit races (round tracks with 5 laps) and sprint races (A to B races, no rules, as fast as possible). The car pimp shop lets you customize you RC car by changing the color, the wheels and the antenna. 3 cars are free and another 15 cars can be unlocked within the game. RC Mini Racers is a fast paced and explosive racing game with 18 remote controlled mini cars, lots of missiles and mines, turbos for an extra boost as well as great hard rock music. 6/13/2023 0 Comments Free image viewerNon-destructive RAW photo editing (like Adobe Lightroom) as well as common image formatsįit to window, zoom, pan, light table, slideshow with effects, OpenGL viewer Lighttable (contact sheet), darkroom (image editing), map, tethering Rotate, flip, save as, used for reading comics and manga. Library organization, RAW and JPEG editing, slideshow tools, print layout and preferences, web gallery creation and uploadingįit to window, zoom, print, full-screen, slideshow, image collection, image information. Via Photoshop: contact sheet, merge to HDR, PDF presentation, photomerge, Web picture gallery Stand Alone: rotate, rename, delete, move, copy, batch rename, add/Edit metadata, camera raw image adjustments: crop, resize, exposure, contrast, white balance, curves Thumbnails, slideshow, filmstrip, preview, versions with alternates Resize, crop, rotate, flip, JPEG lossless rotate/mirror, face recognition, adjust exposure and colors etc., filters (sharpen, blur, average, emboss), red eye removal, batch rename, edit Exif info Thumbnails (user-defined sizes), fullscreen, slideshow, zoom, fit, view Exif info, view inside ZIP archives. This article presents a comparison of image viewers and image organizers which can be used for image viewing.įunctionality overview and licensing Name 6/13/2023 0 Comments Juice wrld conversations lyricsPALMY Boss Bitch - Doja Cat 「Şarkı Sözleri」 - Türkçe Çeviri Get You The Moon (Terjemahan bahasa indonesia) 「Lirik Lagu」 - Kina Bitch i got it off the muscle (TikTok) 「Lyrics」 Bust It Open 「เนื้อเพลง」 - แปลภาษาไทย - Lil Wil Dance Monkey 「Lirik Lagu」 - Terjemahan bahasa indonesia - Tones and I A ROCKET TO THE MOON 「เนื้อเพลง」 - GAVIN.D Miss Me 「Lyrics」 - Joseph Black Anh Thanh Niên - HuyR 「Lời bài hát」 don't stay awake for too long 「Lirik Lagu」 - Terjemahan bahasa indonesia Death Bed 「Lirik Lagu」 - Terjemahan bahasa indonesia - Powfu Lyrics: Throw that ahh back and let me see you do a split (Tik Tok) Eminem - Just the Two of Us 「歌詞」 - 翻訳 日本語で วาฬเกยตื้น เวอร์ชั่นเกาหลี Cover by Kyutae Oppa 「เนื้อเพลง」 don't stay awake for too long 「Lirik Lagu」 - Terjemahan bahasa indonesia Muallimah 「Lirik Lagu」 - Aisyah Istri Rasulullah Chris Brown Antes Que el Mundo Se Acabe 「Letras」 - Residente Skechers - DripReport 「Lirik Lagu」 - Terjemahan bahasa indonesia Joji - XNXX 「TEKST」 XNXX (LYRIC) Joji 「歌词」 - 中文翻译 Melhor Forma 「LETRA」 - Poesia Acústica 9 Joji - XNXX 「Paroles」 - Traduction Française Boss Bitch - Doja Cat 「歌詞」 - 翻訳 日本語で THÍCH THÌ ĐẾN 「Lời bài hát」 - LÊ BẢO BÌNH A ROCKET TO THE MOON 「เนื้อเพลง」 - แปลภาษาไทย - GAVIN.D Melhor Forma 「LETRA」 - Poesia Acústica 9 Cool Company - Bust It Open 「歌詞」 - 翻訳 日本語で Vaaste Song 「Lirik Lagu」 - Terjemahan bahasa indonesia - Dhvani Bhanushali Girls Go Crazy, Number One Baby (Tik Tok) 「Lyrics」 เนื้อเพลง: วาฬเกยตื้น เวอร์ชั่นเกาหลี Cover by Kyutae Oppa Joji - XNXX 「TEKST」 Address It - LPB Poody 「Lirik Lagu」 - Terjemahan bahasa indonesia Death bed 「Lyrics」 - Chinarot version Joji - XNXX 「TEKST」 Anyone - Demi Lovato 「Letras」 - Tradução em Português Tory Lanez - The Take 「Testo」 - Traduzione Italiana GAVIN.D - A ROCKET TO THE MOON - แปลภาษาไทย (เนื้อเพลง) Queen of Disaster - Lana Del Rey 「Lirik Lagu」 - Terjemahan bahasa indonesia Address It - LPB Poody 「Lyrics」 I’m Yer Dad - GRLwood 「Текст」 - Русский перевод No, I Know! 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Marshmello, Polo G & Kid Laroi - Hate The Other Side 「Lyrics」 Juice WRLD - Wishing Well 「Lyrics」 Tainy, J Balvin - Agua (Sponge On The Run) 「Şarkı Sözleri」 - Türkçe Çeviri Tainy, J Balvin - Agua (Sponge On The Run) 「Paroles」 - Traduction Française Tainy, J Balvin - Agua (Sponge On The Run) متن ترانه ترجمه ی فارسی Tainy, J Balvin - Agua (Sponge On The Run) 「歌词」 - 中文翻译 Tainy, J Balvin - Agua (Sponge On The Run) 「Lời bài hát」 - Dịch sang tiếng Việt Tainy, J Balvin - Agua (Sponge On The Run) 「Versuri」 - Traducerea Românească Tainy, J Balvin - Agua (Sponge On The Run) 「Testo」 - Traduzione Italiana Gera MX - SHHH 「LETRA」 Rauf & Faik - закат и рассвет 「Текст」 Dax - My Heart Hurts 「Lyrics」 Julia Vitoria e Aline Barros - Ele Vem (Ao Vivo) 「Lyrics」 MC Bola - Admita Que Me Ama + Sempre Vou Te Amar (DVD Acústico na Laje) 「LETRA」 TikTok: Let Her Go - Passenger 「Lyrics」 TJ_beastboy - LVL UP 「Songtext」 Fard x Kollegah x Asche - SINALOA 「Songtext」 ANIMUS | Hast du Bars ?! | #freestyle2 「Songtext」 Jador❤️Emilia□Dodo□Jay Maly□Costi - JALE 「Songtext」 - Deutsche Übersetzung MIKSU/MACLOUD - XXL (ft. BTS 「Lyrics」 - English Translation Heather - Conan Gray (Acoustic) 「Lyrics」 Kid Cudi, Eminem - The Adventures Of Moon Man & Slim Shady (Lyric Video) 「Lyrics」 Juice WRLD ft.Lyrics Juice WRLD - Wishing Well 「Lyrics」 6/13/2023 0 Comments Short faqt kid actor molenouskyFollow agents on social mediaįollow each of your prospective agencies on Twitter and Facebook. Plus, you will have agencies in your local area who may not be on the list but may be more understanding if you ask for less frequent trips to London. If you’re interested in child modelling too, here’s a modelling agency list īut what works for one family will not work for another. 20 reputable UK talent agencies for child actors (and teen actors).Our lists of talent agencies will get your search started: There are also plenty of talent agencies which mean well but aren’t selective and struggle to build a solid reputation with casting directors. Scam agencies see the parent of an aspiring actor as easy prey. Find reputable talent agenciesīefore you apply to any agency, do lots and lots of research. Musical theatre open audition slots are allocated by the show’s casting director. However, you can apply for numerous roles by subscribing to casting websites. The safest way to find auditions and casting calls for kids is by securing representation with a reputable children’s acting agency. How do you find auditions and casting calls for kids? Alternatively, find the first acting jobs through casting websites. The first stage is finding a reputable children’s acting agency by sending a decent home headshot. Your child can become an actor with no experience if they have the right combination of looks, personality and talent to succeed in casting director workshops. Can your child become an actor with no experience? Secondly, can they cope with rejection? Each child star won breakthrough roles for which hundreds of kids got rejected. Firstly, they must really want to do this themselves, not because you want them to. Just because your child could be a kid actor, doesn’t mean they should be. How can you tell if your child should be an actor? Therefore, they select a young aspiring actor for their books only after an audition workshop. But a reputable children’s talent agency seeks the right combination of looks, personality and talent to suggest the child will win acting roles from casting directors. Does your kid have what it takes to be a child actor?Īn acting teacher spots talent. But roles for film and television roles needs an in-depth understanding of the entertainment industry, a good agent, headshots, showreel, casting website subscriptions, last minute trips to auditions (casting calls), and supporting your child through one rejection after another. Getting your child into acting can be as simple as joining a local acting class, or attending a holiday acting course. If you’re a teenager and aspiring actor please also read out page How to become a teenage actor. This page is written for parents wondering how to get their child into acting and how the children’s acting world works. The employer must also put in safeguarding measures to protect them. They can also do voice acting jobs for radio, TV and film animation, ebooks, and games. Build resilience by coping with frequent rejection after casting calls What is a child actor?Ī child actor is a young actor of pre-school or school age who plays an acting role in theatre, film, TV shows, commercials, music videos, short films or corporate videos.Build up an acting career by working from acting job to acting job.As your child’s career develops, consider an acting coach for competitive roles.Learn other skills that the casting directors may look for – skateboarding, musical instruments etc.Build a network online and with everyone you meet on each acting job.See each audition as practice and accept rejection, as only one child actor wins the role.Gain acting experience in student films, local theatre & other acting opportunities.Compete for elite musical theatre training at a young performers company or acting school.Access quality acting training to improve acting skills and learn acting technique.Apply directly to casting directors for musical theatre open auditions.Investigate other casting websites for child actors.Sign up to Spotlight via your children’s acting agency.Buy photos via the agency’s recommended headshot photographer.Apply to reputable child actor agencies. Take a decent headshot of your child at home or in the garden. 6/13/2023 0 Comments China radio international italiaChina has also developed the Wing Loong II, another medium-altitude, long-endurance drone that has garnered interest from international buyers. The CH-4 has been sold to several countries, including Iraq, Saudi Arabia, and Egypt, and has been used in combat operations in the Middle East. One of the most notable examples of China’s drone prowess is the CH-4, a medium-altitude, long-endurance UAV that bears a striking resemblance to the US’s Reaper drone. This rapid growth has been fueled in part by the Chinese government’s push to become a global leader in cutting-edge technology, as well as by the country’s ability to produce drones at a lower cost than its competitors. The country’s drone exports have surged in recent years, with Chinese-made drones now being used by over 100 countries worldwide. However, recent years have seen other nations, particularly China and Russia, making significant strides in their own drone capabilities.Ĭhina has emerged as a major player in the global drone market, with its military and civilian drone industry growing at an astonishing rate. The Reaper and Predator drones, for example, have become synonymous with the US’s controversial drone warfare program. The United States has long been a leader in drone technology, with its military relying heavily on UAVs for surveillance and targeted strikes. The outcome of this race could have significant implications for the future of warfare, surveillance, and international relations. The United States, China, and Russia are among the nations vying for the top spot in this high-stakes contest, with each country investing heavily in research and development to create the most advanced and lethal drones on the market. The race for drone supremacy is heating up as global powers compete for dominance in the rapidly evolving world of unmanned aerial vehicles (UAVs). The Race for Drone Supremacy: Global Powers Competing for Dominance 6/13/2023 0 Comments The eagles of deathmetalThe death toll inside the venue was 89, including the group's merchandise manager, but the band members escaped safely out of the venue via a door backstage. While the band were on stage at the Bataclan in Paris, France, on November 13, 2015, the audience was attacked by terrorists wielding automatic rifles, grenades and suicide vests. In a 2003 interview, Homme described the sound of the band as a combination of "bluegrass slide guitar mixed with stripper drum beats and Canned Heat vocals." Hughes is known for his enthusiastic interaction with audiences at live performances. The band's current touring line-up includes Hughes alongside Dave Catching (guitar), Eden Galindo (guitar), Jennie Vee (bass) and Jorma Vik (drums).ĭespite their name, Eagles of Death Metal are not a death metal band, and the name is intended to be humorous. Rev your engines, music lovers: Frontier Touring is thrilled to announce high octane rockers Eagles of Death Metal (USA) are headed down under, with eight huge shows announced for Australia and New Zealand in July/August 2023 Long overdue for an Antipodean visit, these will be. Founded by Jesse Hughes (vocals, guitar) and Josh Homme (drums), the band also includes a wide range of other musicians that perform both on the band's studio albums and at live shows. Eagles of Death Metal is an American rock band from Palm Desert, California, formed in 1998. Hughes and Homme are the only permanent members of the band, with Homme rarely performing at live shows due to commitments to his other bands. Eagles of Death Metal is an American rock band from Palm Desert, California, formed in 1998. Founded by Jesse Hughes (vocals, guitar) and Josh Homme (drums), the band also includes a wide range of other musicians that perform both on the band's studio albums and at live shows. Eagles of Death Metal, Queens of the Stone Age, Royal Blood, and more Nick Oliveri on his time in Queens Of The Stone Age and Kyuss Soundsphere Clips 56K views 6 months ago Eagles of Death. Eagles of Death Metal returned to Paris on 7 December to support U2 and performed their song I Love You All the Time, which, in the intervening weeks, had been covered by a wide range of. Eagles of Death Metal is an American rock band from Palm Desert, California, formed in 1998. 6/13/2023 0 Comments Topamax insomnia helpIf both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Drug InteractionsĪlthough certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving topiramate. GeriatricĪlthough appropriate studies on the relationship of age to the effects of topiramate have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of topiramate in the elderly. Safety and efficacy have not been established. Safety and efficacy have not been established.Īppropriate studies have not been performed on the relationship of age to the effects of Trokendi™ extended-release capsules for the treatment of seizures in children younger than 6 years of age.Īppropriate studies have not been performed on the relationship of age to the effects of topiramate capsules, extended-release capsules, tablets, or oral solution for the prevention of migraine headaches in children younger than 12 years of age. However, children are more likely to have unwanted effects (eg, rickets, slow growth, and increased risk of kidney stones) to this medicine. Appropriate studies have not been performed on the relationship of age to the effects of topiramate capsules, oral solution, or tablets, or Qudexy® extended-release capsules to treat seizures in children younger than 2 years of age (when used alone or together with other medicines). 6/13/2023 0 Comments Boot hide out hamilton njZorro made his debut in the 1919 novel The Curse of Capistrano, originally meant as a stand-alone story. In order to divert suspicion about his identity, Diego hides his fighting abilities while also pretending to be a coward and a fop. Diego is usually shown living with his father in a huge hacienda, which contains a number of secret passages and tunnels, leading to a secret cave that serves as headquarters for Zorro's operations and as Tornado's hiding place. In most versions, Diego learned his swordsmanship while at university in Spain, and created his masked alter ego after he was unexpectedly summoned home by his father because California had fallen into the hands of an oppressive dictator. Zorro is the secret identity of Don Diego de la Vega (originally Don Diego Vega), a young man who is the only son of Don Alejandro de la Vega, the richest landowner in California, while Diego's mother is dead. He is also an accomplished rider, his trusty steed being a black horse called Tornado. Zorro is an acrobat and an expert in various weapons, but the one he employs most frequently is his rapier, which he uses often to carve the initial "Z" on his defeated foes, and other objects to "sign his work". Because of this, the townspeople started calling him "El Zorro" due to his foxlike cunning and charm. In the stories, Zorro has a high bounty on his head, but is too skilled and cunning for the bumbling authorities to catch, and he also delights in publicly humiliating them. His signature all-black costume includes a cape, a hat known as a sombrero cordobés, and a mask covering the upper half of his face. He is typically portrayed as a dashing masked vigilante who defends the commoners and indigenous peoples of California against corrupt and tyrannical officials and other villains. Zorro (Spanish for 'fox') is a fictional character created in 1919 by American pulp writer Johnston McCulley, appearing in works set in the Pueblo of Los Angeles in Alta California. |